• Основы медицинской химии

1) A.E. Machulkin, A. A. Uspenskaya, N. Y. Zyk, E. A. Nimenko, A. P. Ber, S. A. Petrov, R. R. Shafikov, D. A. Skvortsov, G. B. Smirnova, Y. A. Borisova, V. S. Pokrovsky, V. S. Kolmogorov, A. N. Vaneev, Y. A. Ivanenkov, A. D. Khudyakov, S. V. Kovalev, A. S. Erofeev, P. V. Gorelkin, E. K. Beloglazkina, N. V. Zyk, E. S. Khazanova, and A. G. Majouga. Psma-targeted small-molecule docetaxel conjugate: Synthesis and preclinical evaluation. European Journal of Medicinal Chemistry, 227:113936, 2022. doi: 10.1016/j.ejmech.2021.113936

2) N. Y. Zyk, A. P. Ber, E. A. Nimenko, R. R. Shafikov, S. A. Evteev, S. A. Petrov, A. A. Uspenskaya, N. S. Dashkova, Y. A. Ivanenkov, D. A. Skvortsov, E. K. Beloglazkina, A. G. Majouga, and A. E. Machulkin. Synthesis and initial in vitro evaluation of psma-targeting ligands with a modified aromatic moiety at the lysine e-nitrogen atom. Bioorganic and Medicinal Chemistry Letters, page 128840, 2022. doi: 10.1016/j.bmcl.2022.128840

3)  A.A. Uspenskaya, E. A. Nimenko, A. E. Machulkin, E. K. Beloglazkina, and A. G. Majouga. The importance of linkers in the structure of psma ligands. Current Medicinal Chemistry, 28, 2021. doi: 10.2174/0929867328666210804092200

4) S. A. Petrov, N. Y. Zyk, A. E. Machulkin, E. K. Beloglazkina, and A. G. Majouga. Psma-targeted low-molecular double conjugates for diagnostics and therapy. European Journal of Medicinal Chemistry, 225:113752, 2021. doi: 10.1016/j.ejmech.2021.113752

5) A.E. Machulkin, R. R. Shafikov, A. A. Uspenskaya, S. A. Petrov, A. P. Ber, D. A. Skvortsov, E. A. Nimenko, N. U. Zyk, G. B. Smirnova, V. S. Pokrovsky, M. A. Abakumov, I. V. Saltykova, R. T. Akhmirov, A. S. Garanina, V. I. Polshakov, O. Y. Saveliev, Y. A. Ivanenkov, A. V. Aladinskaya, A. V. Finko, E. U. Yamansarov, O. O. Krasnovskaya, A. S. Erofeev, P. V. Gorelkin, O. A. Dontsova, E. K. Beloglazkina, N. V. Zyk, E. S. Khazanova, and A. G. Majouga. Synthesis and biological evaluation of psma ligands with aromatic residues and fluorescent conjugates based on them. Journal of Medicinal Chemistry, 64(8):4532–4552, 2021. doi: 10.1021/acs.jmedchem.0c01935

6) A.E. Machulkin, A. A. Uspenskaya, N. U. Zyk, E. A. Nimenko, A. P. Ber, S. A. Petrov, V. I. Polshakov, R. R. Shafikov, D. A. Skvortsov, E. A. Plotnikova, A. A. Pankratov, G. B. Smirnova, Y. A. Borisova, V. S. Pokrovsky, V. S. Kolmogorov, A. N. Vaneev, A. D. Khudyakov, O. E. Chepikova, S. V. Kovalev, A. A. Zamyatnin, A. S. Erofeev, P. V. Gorelkin, E. K. Beloglazkina, N. V. Zyk, E. S. Khazanova, and A. G. Majouga. Synthesis, characterization and preclinical evaluation of small-molecule prostate-specific membrane antigen targeted monomethyl auristatin e conjugate. Journal of Medicinal Chemistry, 64(23):17123–17145, 2021. doi: 10.1021/acs.jmedchem.1c01157

7) S. A. Petrov, A. E. Machulkin, R. A. Petrov, A. N. Tavtorkin, G. N. Bondarenko, S. A. Legkov, I. E. Nifant'ev, V. D. Dolzhikova, N. V. Zyk, A. G. Majouga, and E. K. Beloglazkina. Synthesis and organogelating behaviour of urea- and fmoc-containing diphenylalanine based hexaamide. Journal of Molecular Structure, 1234:130127, 2021. doi: 10.1016/j.molstruc.2021.130127

8) S. A. Petrov, A. E. Machulkin, A. A. Uspenskaya, N. Y. Zyk, E. A. Nimenko, A. S. Garanina, R. A. Petrov, V. I. Polshakov, Y. K. Grishin, V. A. Roznyatovsky, N. V. Zyk, A. G. Majouga, and E. K. Beloglazkina. Polypeptide-based molecular platform for targeted delivery of bimodal agents to psma receptor and its docetaxel/sulfo-cy5-containing conjugate. Molecules, 25(24):5784, 2020. doi: 10.3390/molecules25245784

9) A.A. Larenkov, M. Rakhimov, K. Lunyova, O. Klementyeva, A. Maruk, and A. Machulkin. Pharmacokinetic properties of 68ga-labelled folic acid conjugates: Improvement using hehe tag. Molecules, 25(11):2712, 2020. doi: 10.3390/molecules25112712

10) A.A. Uspenskaya, A. E. Machulkin, E. A. Nimenko, R. R. Shafikov, S. A. Petrov, D. A. Skvortsov, E. K. Beloglazkina, and A. G. Majouga. Influence of dipeptide linker configuration on the activity of psma ligands. Mendeleev Communications, 30:756–759, 2020. doi: 10.1016/j.mencom.2020.11.022

11) A.A. Uspenskaya, A. É. Machulkin, A. G. Mazhuga, and E. K. Beloglazkina. Conjugates of prostate-specific membrane antigen ligands with antitumor drugs. Pharmaceutical Chemistry Journal, 53(4):288–297, 2019. doi: 10.1007/s11094-019-01994-1

12) A.E. Machulkin, D. A. Skvortsov, Y. A. Ivanenkov, A. P. Ber, M. V. Kavalchuk, A. V. Aladinskaya, A. A. Uspenskaya, R. R. Shafikov, E. A. Plotnikova, R. I. Yakubovskaya, E. A. Nimenko, N. U. Zyk, E. K. Beloglazkina, N. V. Zyk, V. E. Koteliansky, and A. G. Majouga. Synthesis and biological evaluation of psma-targeting paclitaxel conjugates. Bioorganic and Medicinal Chemistry Letters, 29(16):2229–2235, 2019. doi: 10.1016/j.bmcl.2019.06.035

13) Y. A. Ivanenkov, R. S. Yamidanov, I. A. Osterman, P. V. Sergiev, V. A. Aladinskiy, A. V. Aladinskaya, V. A. Terentiev, M. S. Veselov, A. A. Ayginin, D. A. Skvortsov, K. S. Komarova, S. V. Sadovnikov, M. Rustam, A. A. Sofronova, A. S. Malyshev, A. E. Machulkin, R. A. Petrov, L. Dmitrii, I. Svetlana, D. S. Bezrukov, A. K. Baymiev, and O. A. Dontsova. 2-pyrazol-1-yl-thiazole derivatives as novel highly potent antibacterials. Journal of Antibiotics, 72:827–833, 2019. doi:  10.1038/s41429-019-0211-y

14) Y. A. Ivanenkov, R. S. Yamidanov, I. A. Osterman, P. V. Sergiev, A. A. Ayginin, V. A. Aladinskiy, A. V. Aladinskaya, V. A. Terentiev, M. S. Veselov, D. A. Skvortsov, K. S. Komarova, A. V. Chemeris, L. F. Zainullina, M. A. Maximova, Z. R. Zileeva, Y. V. Vakhitova, A. K. Baimiev, A. A. Sofronova, A. E. Machulkin, R. A. Petrov, D. S. Bezrukov, M. M. Puchinina, L. A. Dmitrii, and O. A. Dontsova. Substituted furanocoumarins as novel class of antibacterial translation inhibitors. Combinatorial Chemistry and High Throughput Screening, 22(6):400–410, 2019. doi: 10.2174/1386207322666190723110539

15) Y. A. Ivanenkov, A. E. Machulkin, A. S. Garanina, D. A. Skvortsov, A. A. Uspenskaya, E. V. Deyneka, A. V. Trofimenko, E. K. Beloglazkin, N. V. Zyk, V. E. Koteliansky, D. S. Bezruko, A. V. Aladinskaya, N. S. Vorobyeva, M. M. Puchinina, G. K. Ryabykh, A. A. Sofronova, A. S. Malyshev, and A. G. Majouga. Synthesis and biological evaluation of doxorubicin-containing conjugate targeting psma. Bioorganic and Medicinal Chemistry Letters, 29(10):1246–1255, 2019. doi: 10.1016/j.bmcl.2019.01.040

16) N. V. Suvorov, A. E. Machulkin, A. V. Ivanova, A. M. Popkov, E. A. Bondareva, E. A. Plotnikova, R. I. Yakubovskaya, A. G. Majouga, A. F. Mironov, and M. A. Grin. Synthesis of psma-targeted 13- and 15-substituted chlorin e6 derivatives and their biological properties. Journal of Porphyrins and Phthalocyanines, 22(11):1030–1038, 2018. doi: 10.1142/s1088424618501006

17) A.E. Machulkin, A. S. Garanina, O. A. Zhironkina, E. K. Beloglazkina, N. V. Zyk, A. G. Savchenko, V. E. Koteliansky, and A. G. Mazhuga. Nanohybride materials based on magnetite-gold nanoparticles for diagnostics of prostate cancer: Synthesis and in vitro testing. Bulletin of Experimental Biology and Medicine, 161(5):706–710, 2016. doi:  10.1007/s10517-016-3490-3

18) A.E. Machulkin, Y. A. Ivanenkov, A. V. Aladinskaya, M. S. Veselov, V. A. Aladinskiy, E. K. Beloglazkina, V. E. Koteliansky, A. G. Shakhbazyan, Y. B. Sandulenko, and A. G. Majouga. Small-molecule psma ligands. current state, sar and perspectives. Journal of Drug Targeting, 24(8):679–693, 2016. doi: 10.3109/1061186x.2016.1154564

19) Y. A. Ivanenkov, S. V. Vasilevski, E. K. Beloglazkina, M. E. Kukushkin, A. E. Machulkin, M. S. Veselov, N. V. Chufarova, A. Vanzcool, N. V. Zyk, D. A. Skvortsov, A. A. Khutornenko, A. L. Rusanov, A. G. Tonevitsky, O. A. Dontsova, and A. G. Majouga. Design, synthesis and biological evaluation of novel potent mdm2/p53 small-molecule inhibitors. Bioorganic and Medicinal Chemistry Letters, 25(2):404–409, 2015. doi: 10.1016/j.bmcl.2014.09.070